– Newly published data from real-world European clinical practice has shown that XultophyR (insulin degludec/liraglutide) significantly reduced blood sugar levels in people with type 2 diabetes after six months.[1] The study looked at people with type 2 diabetes who were treatment-na?ve or who had been switched to treatment with XultophyR from any combination of oral antidiabetic drugs, glucagon-like peptide-1 (GLP-1) analogues, and/or insulin regimens in real-world clinical practice.[1]
In the study population, XultophyR delivered a significant overall decrease in mean blood sugar (HbA1c) of 0.9% to 7.5% at six months. Regardless of which treatment the study participants were switched from, the average decrease in blood sugar was significant.[1] The average dose of XultophyR was 30 dose steps (representing 30 units of insulin) at six months, significantly lower than 50 dose steps which is the maximum approved dose of XultophyR.[1]
“It’s exciting to see that XultophyR delivers significant benefits to people with type 2 diabetes in such a short period of time and in a real-world setting, providing better blood sugar control with just one injection per day regardless of previous treatment,” said Mads Krogsgaard Thomsen, executive vice president and chief science officer at Novo Nordisk.
Hypoglycaemia (low blood sugar) rates were reduced by 82% in the six month period after initiating XultophyR, compared to the six month period before. Furthermore, average body weight was significantly reduced by 0.7 kg after six months of treatment vs baseline.[1]
About the EXTRA study
The European XultophyRTreatment Retrospective Audit (EXTRA) study was a European, multicentre, retrospective chart review which included 611 people with type 2 diabetes ≥ 18 years of age, who started on XultophyR at least six months prior to the start of the study. Blood sugar levels, body weight and rate of hypoglycaemic events were measured at baseline (up to six months before starting on XultophyR) and at 3, 6, 9 and 12 months after initiating XultophyR. Data was collected from clinics in Germany (n=450), Switzerland (n=84), the UK (n=44), Austria (n=19) and Sweden (n=14).[1]
The study was published in the peer-reviewed journal Diabetes, Obesity and Metabolism.[1]
About XultophyR
XultophyR is a once-daily single injection fixed-ratio combination of long-acting insulin degludec and the glucagon-like peptide-1(GLP-1) receptor agonist liraglutide in one pen. It is indicated for the treatment of adults with type 2 diabetes mellitus to improve glycaemic control in combination with oral glucose-lowering medicinal products when these alone or combined with a GLP-1 receptor agonist or basal insulin do not provide adequate glycaemic control. XultophyR can be administered at any time of the day with or without meals, preferably at the same time of the day.[2]
About Novo Nordisk
Novo Nordisk is a global healthcare company with more than 90 years of innovation and leadership in diabetes care. This heritage has given us experience and capabilities that also enable us to help people defeat other serious chronic conditions: haemophilia, growth disorders and obesity. Headquartered in Denmark, Novo Nordisk employs approximately 41,400 people in 77 countries and markets its products in more than 165 countries. For more information, visitnovonordisk.com,Facebook,Twitter,LinkedIn,YouTube
References
1. Price H, Bluher M, Prager R, et al. Use and effectiveness of a fixed-ratio combination of insulin degludec/liraglutide (IDegLira) in a real-world population with type 2 diabetes: Results from a European, multicentre, retrospective chart review study. Diabetes Obes Metab. 2017. http://dx.doi.org/10.1111/dom.13182.
2. EMA. XultophyR Summary of Product Characteristics. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002647/WC500177657.pdf. Last accessed: December 2017.
Further information
Media: Katrine Sperling +45-4442-6718 [email protected]?sa Josefsson +45-3079-7708 [email protected] Investors: Peter Hugreffe Ankersen +45-3075-9085 [email protected]Hanna Ogren +45-3079-8519 [email protected]Anders Mikkelsen +45-3079-4461 [email protected]Christina Kj?r +45-3079-3009 [email protected]Kasper Veje (US) +1-609-235-8567 [email protected]
(Immediapress – Adnkronos
Immediapress e’ un servizio di diffusione di comunicati stampa in testo originale redatto direttamente dall’ente che lo emette. Padovanews non e’ responsabile per i contenuti dei comunicati trasmessi.)